10Man Falling Apart

Has anyone noticed it is hard to moderate a ten man or God knows a 25 man group! Last week my 10 man lost our 2 healers, and top two DPS to run with RL friends. The week before we ran to Thadius but only had time for two attempts. The polarity was confusing for people. I think for only running naxx for 5 weeks we have done well. After replacing the lost healers (a priest and paladin) with a new Priest and Druid and the DPS (mage and DK) with a Shaman and Hunter we were stuck at Grob. That fight is a real pain. I consider it the hardest fight in the 10 man game short of hard modes like 3D. Anyway, this week we are losing 2 more DPS due to softball and college finals. I totally agree that RL should come first, running a raid group is just getting very frustrating. Goodbye top two DPS...again